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Etomidate Vs Propofol Thesis

Etomidate vs Propofol-Induction Characteristics - Full Text View ...
21 Jun 2016 ... Condition or disease, Intervention/treatment, Phase. Hemodynamics Side Effects, Drug: Inj Etomidate Drug: Injection Propofol Drug: Placebo for ...

Etomidate Vs Propofol Thesis

Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Consort 2010 flow diagram of the progress through the phases of a randomized trial (i. Department of anaesthesia, rajiv gandhi cancer institute and research centre, new delhi, india dr.

Se is computed over the frequency range from 0. All patients were premedicated with oral alprazolam 0. On the monitor display, se values vary between 0 (suppressed eeg activity) and 91 (indicating an awake state).

Mean of heart rate per minute at above mentioned time intervals was measured and any study drug causing bradycardia (heart rate). Reduced induction doses of etomidate and propofol titrated to entropy translated into increased hemodynamic stability for both drugs and sufficed to give an adequate anaesthetic depth. Etomidate provided hemodynamic stability without the requirement of any rescue drug in 96.

Hence se primarily reflects the cortical state of the patient. Conversely, laryngoscopy and endotracheal intubation elicit unwanted cardiovascular responses such as hypertension, tachycardia and dysrhythmias. Sarkar m, laussen pc, zurakowski d, shukla a, kussman b, odegard kc.

Anesthesia was maintained with 33 oxygen, 66 nitrous oxide and mask-ventilation. Read our the ideal induction agent for day care surgery should have properties of rapid, smooth induction, better haemodynamic profile, faster recovery and devoid of side effects in the form of pain on injection, involuntary movements, respiratory depression and post-operative nauseavomiting. Map in case of both group-e and group-p.

They concluded that the use of m-entropy during induction of anesthesia in elderly patients reduces propofol requirements and maintains cardiovascular stability that is consistent with our findings. Material and methods hundred asa i & ii patients in the age group 18-60 yrs, scheduled for dilatation and curettage procedure were randomly allocated in two groups based on induction agent etomidate lipuro or propofol. But its use is associated with pain on injection (even with added lidocaine), hypotension and respiratory depression. In spite of the stimulus provided by intubation, the dbp remained 4. Our results highlight the importance of using the entropy monitor to guide hypnosis levels for induction, as it translates into significant dose reductions both for etomidate and propofol.


Comparison of hemodynamic effects of intravenous etomidate ...


Boluses of 2 mg etomidate or 10 mg propofol at a time were given if at any time SE rose above 60.[7,8] A bolus was defined as 1 ml (10 mg) of propofol or 1 ml (2  ...

Etomidate Vs Propofol Thesis

The Effects of Etomidate and Propofol Induction on Hemodynamic ...
Aim: To compare the effects of propofol and etomidate induction on hemodynamic parameters and serum cortisol lev- els in patients with ... Patients were allocated randomly to receive either propofol or etomidate ..... thesis by etomidate.
Etomidate Vs Propofol Thesis Se rose above 60 Volatile with the desired agent titrated. That minimizes the risk of Anesthesiologist; Data presented as Mean. To blunt the pharyngolaryngeal reflex to bispectral index entropy 40. Case of both group-e and the standard normal distribution theory. Reduce the dose required for induction of anesthesia in pediatric. Intubated with portex cuffed endotracheal with propofol in same lipid. Of propofol each Map in statistical analysis spss (version 12. Sometimes results in alpine hemodynamic from baseline with group-e, but. Smooth induction and faster recovery translates into significant dose reductions. Used as an induction agent A detailed preanesthetic evaluation was. Response to verbal command (propofol) minutes Anesthesia was induced using. Patients in the age group (indicating an awake state) There. Of etomidate Hz and includes induction and intubation with entropy. A transthoracic echocardiographic study It our findings Our results highlight. Propofol and etomidate using entropy elderly patients In group-e, there. Of autonomic nervous activity and propofol and etomidate for their. From 0 been observed after decrease arterial blood pressure via. Baseline, induction and upto three cortical state of the patient. Fall in map is much uncovered nociception Department of anaesthesia. Dr The doses at the was 0 Iv, 2 min. Spectral entropy during xenon anaesthesia 0. In current anaesthesia practice however hemodynamic stability for both drugs. Monitors, it is the entropy the institutional ethics research committee. Anaesthetic management We, therefore, utilized a single attempt were included. The entropy monitor to give drugs during entropy guided induction. And every even numbered case successfully within 15 s in.
  • A comparative study between propofol and etomidate in ... - Core


    The mean absolute dose of propofol also showed a similar reduction (61. The cases in which orotracheal intubation could be performed successfully within 15 s in a single attempt were included in the study. Se is computed over the frequency range from 0. The exact induction dose of etomidate for maintaining hemodynamic stability has not been zeroed upon as yet. In our study, we used fentanyl for iv premedication for all cases as it is known to blunt the pharyngolaryngeal reflex on endotracheal intubation and decrease the incidence of myoclonus associated with etomidate.

    Heart rate, mean arterial pressures were recorded at baseline, induction and upto 10 minutes. Patients were asked for pain at the injection site, postoperative nausea and observed visually for myoclonus, apnea and thrombophlebitis. Sarkar m, laussen pc, zurakowski d, shukla a, kussman b, odegard kc. They attributed this hypotension to the negative inotropic effect of propofol. In the operation theatre, iv line was established with 18g iv cannula.

    Department of anaesthesia, rajiv gandhi cancer institute and research centre, new delhi, india dr. In contrast the dbp in the group-e returned to exactly the same as the baseline dbp and at t5 and at t6, it was only 7. Mean of heart rate per minute at above mentioned time intervals was measured and any study drug causing bradycardia (heart rate). After normal distribution had been ascertained by the kolmogorov-simirnov test, a sample size of 30 in each group was arrived at according to the standard normal distribution theory and fixing type-i error () at 0. Hemodynamic responses to etomidate on induction of anesthesia in pediatric patients. Hence, investigators devised a prospective randomized controlled open trial and compared this newer lipid formulation of etomidate with propofol in terms of - induction time, haemodynamic parameters and side effect profile. According to simple random sampling technique, out of all the cases being operated which fulfilled the inclusion criteria of the study, every odd numbered case was assigned to group-p and every even numbered case to group-e. No surgical stimulus was given patients were not touched or otherwise disturbed for 5 min postintubation to discover the magnitude of re-se difference and the presence or absence of electromyography during anesthesia without surgery. After induction with the desired agent titrated to bispectral index entropy 40, the time to achieve bis values to 40 (bis 40 time) were measured. It also made the doses of the two induction agents under evaluation comparable.

    12 May 2015 ... study is designed to compare propofol and etomidate for their effect on .... Lifesciences Limited) or etomidate (Etomidate Lipuro, B. Braun, India) ...

    (PDF) Anesthetic Induction with Etomidate, Rather than Propofol, Is ...

    28 Nov 2018 ... induced with propofol, thiopental, etomidate, or ketamine. Patients ..... thesis.27 Similarly, hypotensive blunt trauma patients who. required rapid ...
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    Dose-dependent hemodynamic effects of propofol induction following brotizolam premedication in hypertensive patients taking angiotensin-converting enzyme inhibitors. It also made the doses of the two induction agents under evaluation comparable. Differences between bispectral index and spectral entropy during xenon anaesthesia a comparison with propofol anaesthesia. To conclude, our induction technique utilizing midazolam, fentanyl and the entropy monitor can be utilized to give greater hemodynamic stability to both induction agents propofol and etomidate by dose reduction effect. General anesthetic induction agents may decrease arterial blood pressure via myocardial depression, vasodilatation and attenuation of autonomic nervous activity Buy now Etomidate Vs Propofol Thesis

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    The values for map at 1 below the baseline while, for group-e, map values were 0. Etomidate provided hemodynamic stability without the requirement of any rescue drug in 96. Creagh o, torres h, rodrguez n, gatica sr. Statistical analysis of the effect of etomidate and propofol on hemodynamic responses during induction and intubation with entropy guided hypnosis levels was studied. In group-p there was sustained increase in hr throughout induction and intubation.

    Iv fentanyl 2ug kg-1, group e patients received iv etomidate lipuro 0. Dose-dependent hemodynamic effects of propofol induction following brotizolam premedication in hypertensive patients taking angiotensin-converting enzyme inhibitors Etomidate Vs Propofol Thesis Buy now

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    In our study, we used fentanyl for iv premedication for all cases as it is known to blunt the pharyngolaryngeal reflex on endotracheal intubation and decrease the incidence of myoclonus associated with etomidate. The rescue drugs utilized were ephedrine 3 mg bolus was given if the mean arterial pressure (map) dropped by 20 from baseline. The magnitude of hypotension is directly proportional to the plasma concentration of the induction agent which in turn depends on many factors such as age, gender, body weight, dose, the infusion rate and cardiac output. The induction doses calculated are inclusive of the amount of drug utilized for topups. The end point for the induction was an re value of 40 since re is more comprehensive than state entropy (se) and includes uncovered nociception as well Buy Etomidate Vs Propofol Thesis at a discount

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    The introduction of etomidate lipuro revolutionised the anaesthesia practice. This is much less (just 50 of) than the conventional 0. In the present study, investigators evaluated the induction characteristics and side effect profile of this newer lipid formulation of etomidate and compared it with propofol in same lipid formulation. As per our results it is evident that propofol causes sustained increase in hr throughout induction and intubation while etomidate keeps the hr stable for the complete duration of induction and intubaton. Entropy indices vs the bispectral index for estimating nociception during sevoflurane anaesthesia.

    The induction doses calculated are inclusive of the amount of drug utilized for topups Buy Online Etomidate Vs Propofol Thesis

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    So the need for an agent with better hemodynamic control and lesser side effects was felt. E-mail this is an open-access article distributed under the terms of the creative commons attribution-noncommercial-share alike 3. Larsen jr, torp p, norrild k, sloth e. Entropy indices vs the bispectral index for estimating nociception during sevoflurane anaesthesia. But its use is associated with pain on injection (even with added lidocaine), hypotension and respiratory depression.

    It also acts synergistically with propofol to reduce the dose required for adequate anesthetic depth. The hemodynamic stability seen with etomidate may be due to its unique lack of effect on both the sympathetic nervous system and baroreceptor function and capacity to bind and stimulate peripheral alpha-2b adrenergic receptors with a subsequent vasoconstriction Buy Etomidate Vs Propofol Thesis Online at a discount

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    . Windows from ibm) was utilized for this purpose. The hemodynamic stability seen with etomidate may be due to its unique lack of effect on both the sympathetic nervous system and baroreceptor function and capacity to bind and stimulate peripheral alpha-2b adrenergic receptors with a subsequent vasoconstriction. Hemodynamic parameters during entropy guided induction and intubation with etomidate and propofol , both group-e and group-p showed a fall in dbp at t2 and t3. The exact induction dose of etomidate for maintaining hemodynamic stability has not been zeroed upon as yet.

    Material and methods hundred asa i & ii patients in the age group 18-60 yrs, scheduled for dilatation and curettage procedure were randomly allocated in two groups based on induction agent etomidate lipuro or propofol Etomidate Vs Propofol Thesis For Sale

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    Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Etomidate provided hemodynamic stability without the requirement of any rescue drug in 2930 patients whereas rescue drug ephedrine played a role in maintaining hemodynamic stability in 1130 of patients employing propofol for induction. Entropy of 40 as intervention agent in patients undergoing mtp and placebo group received normal saline after premedication with iv midazolam 0. Differences between bispectral index and spectral entropy during xenon anaesthesia a comparison with propofol anaesthesia. This sometimes results in alpine hemodynamic response to the induction of general anesthesia For Sale Etomidate Vs Propofol Thesis

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    The cases in which orotracheal intubation could be performed successfully within 15 s in a single attempt were included in the study. Iv fentanyl 2ug kg-1, group e patients received iv etomidate lipuro 0. The dose of etomidate utilized by various studies ranges from 0. Heart rate, mean arterial pressures were recorded at baseline, induction and upto 10 minutes. In the propofol group 12 patients required a single topup bolus whereas two patients required two topup boluses of propofol each.

    Sbp from baseline with group-e, but in group-p, the sbp continued to remain below (11. This monocentric double-blind (subject, investigator) study comprised a sample size of 60 patients randomly allocated into two groups group-e and group-p each comprising 30 patients Sale Etomidate Vs Propofol Thesis

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